                         SEQUENCE LISTING

<110>  THE CHILDREN'S HOSPITAL OF PHILADELPHIA
       DAVIDSON, Beverly  L.
       MONTEYS, Alejandro Mas
       KEISER, Megan  S.
 
<120>  THERAPEUTIC FOR TREATMENT OF DISEASES INCLUDING THE CENTRAL 
       NERVOUS SYSTEM

<130>  074659-0451689

<140>  PCT/US2017/022973
<141>  2017-03-17

<150>  62/310,229
<151>  2016-03-18

<150>  62/367,858
<151>  2016-07-28

<160>  8     

<170>  PatentIn version 3.5

<210>  1
<211>  3774
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Stuffer Sequence

<400>  1
gaattcaggc tatcccaggt tgccttggtt cttggcaatt gggaaattaa gagggcagag       60

agaatttgaa cagaaactgt tctaatattg gtcttttatt gtgtaagtat tgttctttgg      120

taaacctcct tcttttggtt tccaggaatt gctggacaca gtggcttggt gtgtgtctga      180

ggactgtagg ccttggccct aggttgtggt tttaggtctc aggtgctctt cctggctgtc      240

tccttgcttc tttcccttgt cctcttcttt gtttccagcc ttttctccct tttgcttaag      300

tttggtgcag cagggtttgg ctgctctcag attcctgctt cctcagttgc tgtagttgtc      360

aggcccagaa ggctggcaga aggatcagga tctggctagg tttgctctca ctgtggcaga      420

gtagggggag gaggagagca aaagtgaccc caggccagct gtagggagct taggcttggt      480

caaccagcct tcaggtccta gactttgtct tctcttgagt ttggctgtgt gtgtttggtg      540

ggaactaggt tctacttagc ccaagaaatt gggcactttt tgcttgtggt ttctgtagag      600

aattgcactg ggtatctgac ttagcctggc agcttgcctc cctcaggtag gttagtctca      660

ggaagtgaag caaagtccag caagaacttc ttttgtggct taaagtctca attctgtgag      720

gtgctggcaa atcaccacca caatcaagag gctgaagtga tttttgtcta gggaggcagg      780

aaaggcttcc tggagtcagc agccagtagg tgaaagagta gattggagac cttcttaatc      840

ttcacaacct cttgtctcaa ggggtgccag gaagctgtgg aggctgaacc cttcttttgc      900

tgccagagag tgggacacct tgagggtcag gtcaaggggt tgtaccttgt ttggtagaga      960

attaggggct cttgaagact ttggttgtgg tcaggggagt gtatctttta ggaagagtga     1020

ccaagtgagg aagggtagag gaggacaggt gggagggagt ccaggtggga gtgagtagac     1080

ccagcaggag tgcagggcct aaagccaggt tggtggcagg gctgtgagga gaggcagcca     1140

cctgtgtgtc tgaagaagca ggggcaagag ggaagaggcc agcagactgc cttcacccag     1200

aaactggaat agattgtgag agacctttcc ctgctcttag gaggggctga gttccagtcc     1260

tctcttgtta tacaaggggc ttggtatttg tttacaaaag gggtgtaaag ctagggcaag     1320

gtttgataag gcttctaggg gtatttaaga agtattgttg gggtaattgt ttgtccaatt     1380

aactttgctc ttggaaggac tttcagtaca aactgcaaca acaggattag gaagggaaaa     1440

tttctgagtt ggggttactc ctcagaattt cccagattgt gatctggttt tgattttcaa     1500

gcttgctgac ccaataggtt aacccacaag ttttaaccag accttctcag tccacttact     1560

tcaactgccc ttgccaaagt ccaagagatc ttaaactgtt gtttggcaca gcttcctccc     1620

tcttgggtgg gcaagctttt ggaagagaag gctcctttgg gtgagagtgg ggcaccaaag     1680

tcttccctgt cccttcccct agcttgagaa gcccttctct attgtggact ttgtgcaatt     1740

agcttaatta ctagcttgaa gttgaccttc tggaaatact ttctggttta gcctcacaag     1800

tgagcaagga gggttgagag ttgtgctgtg aggattgtgg ggccccagct ggcagcaggc     1860

tctgggtcag gggggcaggg accaaaggct tacctgacag tgaggagggg tctagtaggg     1920

gatcagttcc cctgttgttc tttagaacct tctggatatt cttcttccct gattgggggt     1980

tgtgaacaat agaatcaact tctacttgta gattgattta gggagaactt atacctcagt     2040

tgttaagtca ccctgtccag attgtgggtt gctttcctat ttgttcagaa ctttcccaat     2100

tacctcagaa gcacttgaaa tttaaaggat tttaacccca acttagggat tatttcactt     2160

agctcttgca cttttcttga taattgaatc ctcaggtatt cctctgtttg ggttactaat     2220

agttacttct tttggggggg ttttcccctg aaaatctttt atccccaatt tgtggcttac     2280

cctctgaagg ttgtttgata attttggaag atttgaaagt cttcttattt tacaaggttt     2340

ggggtctctt taagctgctt ggttctcttg tcagctccca aagcagaaga aagctagctg     2400

aaaattgcaa tagagaagat acttcttttc cacctgtttt caactcttat cttcttgaat     2460

ttcagggcac ctttccttgc tcctagtgct tgctatctgt ttattatttt ccttcctgaa     2520

taccctgaac tccagcttgt tctgctgtaa ttctggcctc cctggcttct tggactcctg     2580

tttcctttgc tctgtcttcc cccaagtcag ctcctgctga acagcttctc agctgaagtg     2640

aacctggagt gcctggatct tgctggatct ttgagtattg cctctggggt ccttggttcc     2700

ttctgctgag ttgctcagaa tctccactcc cccaaccttg tgtggccctt cctgcactcc     2760

tctgattccc cttgtcttcc ctggtttctt gctttggttt aaagtctcca cagaactttt     2820

gcagctcttc tgaagacctg gaagcttttt cttcttaatt ctcttctctt gacctctttt     2880

cccttctttg agagctagaa cttcccttgg tgaacttctc tttccagaat tacttgcctt     2940

cttttccctc ccacttacct gttgtccagg agaggtcaga ttgctgtgct tattggagga     3000

gaaccctttc ttccctgggc tcttcttctc acttgacttc accacttcac ctaattcctt     3060

ggaccctcag tggtgtcact gctggatttt tctttccttt ggctggcctt agggcacacc     3120

caggttgact agaatagtct tggtatttag atccactcac tttttcagtt tctgtgtctg     3180

tctcttgcct gcttctgact taacccagag aaagcttctc tttcacaagg gttcttagat     3240

ttttgttcac tgagcacctt cttttctgag gcagtgtttt accaataggg gttttcctag     3300

tcagtctaac cttacctttc ttgttgggct tgtctttggt cctgaccctt tctctgagtc     3360

tgtaacccag aattgctgta taacccaatt acttgaaatc ctttagaatc ttaacacttc     3420

ttacacctga tttccccttt tattgtatcc aaattgaacc aaccctttgt gaatttgaca     3480

gtgatttctc ccagggatcc tagtgtataa ggaataggac ttagtatttt ctattggggg     3540

atataccact taccagatac tgattttgtt ggacttttaa cccttttttc tctttttgaa     3600

agaaagttag gaattatttc ttccagtaga accagtgtaa cctgaaagcc tttgaaagag     3660

tagtttgggt atagctatct gaaaggaatt tctttccaag ggatttcccc agtgctgaca     3720

acaaacaaac agacacaccc tgcaaggtga gtgtaaagaa cactagagca aggc           3774


<210>  2
<211>  4599
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Vector Sequence

<400>  2
ctgcgcgctc gctcgctcac tgaggccgcc cgggcgtcgg gcgacctttg gtcgcccggc       60

ctcagtgagc gagcgagcgc gcagagaggg agtggccaac tccatcacta ggggttcctt      120

gtagttaatg attaacccgc catgctactt atctacgtag ccatgctcta gtgaattcga      180

cgccgccatc tctaggcccg cgccggcccc ctcgcacaga cttgtgggag aagctcggct      240

actcccctgc cccggttaat ttgcatataa tatttcctag taactataga ggcttaatgt      300

gcgataaaag acagataatc tgttcttttt aatactagct acattttaca tgataggctt      360

ggatttctat aagagataca aatactaaat tattatttta aaaaacagca caaaaggaaa      420

ctcaccctaa ctgtaaagta attgtgtgtt ttgagactat aaatatccct tggagaaaag      480

ccttgtttgc gtttagtgaa ccgtcagatg gtaccgttta aactcgagtg agcgcagcaa      540

cgacctgaag atcgatccgt aaagccacag atggggtcga tcttcaggtc gttgcttcgc      600

ctactagagc ggccgccaca gcggggagat ccagacatga taagatacat tttttgaatt      660

caggctatcc caggttgcct tggttcttgg caattgggaa attaagaggg cagagagaat      720

ttgaacagaa actgttctaa tattggtctt ttattgtgta agtattgttc tttggtaaac      780

ctccttcttt tggtttccag gaattgctgg acacagtggc ttggtgtgtg tctgaggact      840

gtaggccttg gccctaggtt gtggttttag gtctcaggtg ctcttcctgg ctgtctcctt      900

gcttctttcc cttgtcctct tctttgtttc cagccttttc tcccttttgc ttaagtttgg      960

tgcagcaggg tttggctgct ctcagattcc tgcttcctca gttgctgtag ttgtcaggcc     1020

cagaaggctg gcagaaggat caggatctgg ctaggtttgc tctcactgtg gcagagtagg     1080

gggaggagga gagcaaaagt gaccccaggc cagctgtagg gagcttaggc ttggtcaacc     1140

agccttcagg tcctagactt tgtcttctct tgagtttggc tgtgtgtgtt tggtgggaac     1200

taggttctac ttagcccaag aaattgggca ctttttgctt gtggtttctg tagagaattg     1260

cactgggtat ctgacttagc ctggcagctt gcctccctca ggtaggttag tctcaggaag     1320

tgaagcaaag tccagcaaga acttcttttg tggcttaaag tctcaattct gtgaggtgct     1380

ggcaaatcac caccacaatc aagaggctga agtgattttt gtctagggag gcaggaaagg     1440

cttcctggag tcagcagcca gtaggtgaaa gagtagattg gagaccttct taatcttcac     1500

aacctcttgt ctcaaggggt gccaggaagc tgtggaggct gaacccttct tttgctgcca     1560

gagagtggga caccttgagg gtcaggtcaa ggggttgtac cttgtttggt agagaattag     1620

gggctcttga agactttggt tgtggtcagg ggagtgtatc ttttaggaag agtgaccaag     1680

tgaggaaggg tagaggagga caggtgggag ggagtccagg tgggagtgag tagacccagc     1740

aggagtgcag ggcctaaagc caggttggtg gcagggctgt gaggagaggc agccacctgt     1800

gtgtctgaag aagcaggggc aagagggaag aggccagcag actgccttca cccagaaact     1860

ggaatagatt gtgagagacc tttccctgct cttaggaggg gctgagttcc agtcctctct     1920

tgttatacaa ggggcttggt atttgtttac aaaaggggtg taaagctagg gcaaggtttg     1980

ataaggcttc taggggtatt taagaagtat tgttggggta attgtttgtc caattaactt     2040

tgctcttgga aggactttca gtacaaactg caacaacagg attaggaagg gaaaatttct     2100

gagttggggt tactcctcag aatttcccag attgtgatct ggttttgatt ttcaagcttg     2160

ctgacccaat aggttaaccc acaagtttta accagacctt ctcagtccac ttacttcaac     2220

tgcccttgcc aaagtccaag agatcttaaa ctgttgtttg gcacagcttc ctccctcttg     2280

ggtgggcaag cttttggaag agaaggctcc tttgggtgag agtggggcac caaagtcttc     2340

cctgtccctt cccctagctt gagaagccct tctctattgt ggactttgtg caattagctt     2400

aattactagc ttgaagttga ccttctggaa atactttctg gtttagcctc acaagtgagc     2460

aaggagggtt gagagttgtg ctgtgaggat tgtggggccc cagctggcag caggctctgg     2520

gtcagggggg cagggaccaa aggcttacct gacagtgagg aggggtctag taggggatca     2580

gttcccctgt tgttctttag aaccttctgg atattcttct tccctgattg ggggttgtga     2640

acaatagaat caacttctac ttgtagattg atttagggag aacttatacc tcagttgtta     2700

agtcaccctg tccagattgt gggttgcttt cctatttgtt cagaactttc ccaattacct     2760

cagaagcact tgaaatttaa aggattttaa ccccaactta gggattattt cacttagctc     2820

ttgcactttt cttgataatt gaatcctcag gtattcctct gtttgggtta ctaatagtta     2880

cttcttttgg gggggttttc ccctgaaaat cttttatccc caatttgtgg cttaccctct     2940

gaaggttgtt tgataatttt ggaagatttg aaagtcttct tattttacaa ggtttggggt     3000

ctctttaagc tgcttggttc tcttgtcagc tcccaaagca gaagaaagct agctgaaaat     3060

tgcaatagag aagatacttc ttttccacct gttttcaact cttatcttct tgaatttcag     3120

ggcacctttc cttgctccta gtgcttgcta tctgtttatt attttccttc ctgaataccc     3180

tgaactccag cttgttctgc tgtaattctg gcctccctgg cttcttggac tcctgtttcc     3240

tttgctctgt cttcccccaa gtcagctcct gctgaacagc ttctcagctg aagtgaacct     3300

ggagtgcctg gatcttgctg gatctttgag tattgcctct ggggtccttg gttccttctg     3360

ctgagttgct cagaatctcc actcccccaa ccttgtgtgg cccttcctgc actcctctga     3420

ttccccttgt cttccctggt ttcttgcttt ggtttaaagt ctccacagaa cttttgcagc     3480

tcttctgaag acctggaagc tttttcttct taattctctt ctcttgacct cttttccctt     3540

ctttgagagc tagaacttcc cttggtgaac ttctctttcc agaattactt gccttctttt     3600

ccctcccact tacctgttgt ccaggagagg tcagattgct gtgcttattg gaggagaacc     3660

ctttcttccc tgggctcttc ttctcacttg acttcaccac ttcacctaat tccttggacc     3720

ctcagtggtg tcactgctgg atttttcttt cctttggctg gccttagggc acacccaggt     3780

tgactagaat agtcttggta tttagatcca ctcacttttt cagtttctgt gtctgtctct     3840

tgcctgcttc tgacttaacc cagagaaagc ttctctttca caagggttct tagatttttg     3900

ttcactgagc accttctttt ctgaggcagt gttttaccaa taggggtttt cctagtcagt     3960

ctaaccttac ctttcttgtt gggcttgtct ttggtcctga ccctttctct gagtctgtaa     4020

cccagaattg ctgtataacc caattacttg aaatccttta gaatcttaac acttcttaca     4080

cctgatttcc ccttttattg tatccaaatt gaaccaaccc tttgtgaatt tgacagtgat     4140

ttctcccagg gatcctagtg tataaggaat aggacttagt attttctatt gggggatata     4200

ccacttacca gatactgatt ttgttggact tttaaccctt ttttctcttt ttgaaagaaa     4260

gttaggaatt atttcttcca gtagaaccag tgtaacctga aagcctttga aagagtagtt     4320

tgggtatagc tatctgaaag gaatttcttt ccaagggatt tccccagtgc tgacaacaaa     4380

caaacagaca caccctgcaa ggtgagtgta aagaacacta gagcaaggct acgtagataa     4440

gtagcatggc gggttaatca ttaactacaa ggaaccccta gtgatggagt tggccactcc     4500

ctctctgcgc gctcgctcgc tcactgaggc cgggcgacca aaggtcgccc gacgcccggg     4560

ctttgcccgg gcggcctcag tgagcgagcg agcgcgcag                            4599


<210>  3
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Stuffer Sequence

<400>  3
ggucgaucuu caggucguug cuu                                               23


<210>  4
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Stuffer Sequence

<400>  4
ggtcgatctt caggtcgttg ctt                                               23


<210>  5
<211>  86
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Stuffer Sequence

<400>  5
ctcgagtgag cgcagcaacg acctgaagat cgatccgtaa agccacagat ggggtcgatc       60

ttcaggtcgt tgcttcgcct actaga                                            86


<210>  6
<211>  119
<212>  DNA
<213>  Adeno-associated virus

<400>  6
ctgcgcgctc gctcgctcac tgaggccgcc cgggcgtcgg gcgacctttg gtcgcccggc       60

ctcagtgagc gagcgagcgc gcagagaggg agtggccaac tccatcacta ggggttcct       119


<210>  7
<211>  130
<212>  DNA
<213>  Adeno-associated virus

<400>  7
aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg       60

ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc      120

gagcgcgcag                                                             130


<210>  8
<211>  11591
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Stuffer Sequence

<400>  8
gacgcgccct gtagcggcgc attaagcgcg gcgggtgtgg tggttacgcg cagcgtgacc       60

gctacacttg ccagcgccct agcgcccgct cctttcgctt tcttcccttc ctttctcgcc      120

acgttcgccg gctttccccg tcaagctcta aatcgggggc tccctttagg gttccgattt      180

agtgctttac ggcacctcga ccccaaaaaa cttgattagg gtgatggttc acgtagtggg      240

ccatcgccct gatagacggt ttttcgccct ttgacgttgg agtccacgtt cttaatagtg      300

gactcttgtt ccaaactgga acaacactca accctatctc ggtctattct tttgatttat      360

aagggatttt gccgatttcg gcctattggt taaaaaatga gctgatttaa caaaaattta      420

acgcgaattt taacaaaata ttaacgctta caatttaggt ggcacttttc ggggaaatgt      480

gcgcggaacc cctatttgtt tatttttcta aatacattca aatatgtatc cgctcatgag      540

acaataaccc tgataaatgc ttcaataata ttgaaaaagg aagagtatga gccatattca      600

acgggaaacg tcttgctcga agccgcgatt aaattccaac atggatgctg atttatatgg      660

gtataaatgg gctcgcgata atgtcgggca atcaggtgcg acaatctatc gattgtatgg      720

gaagcccgat gcgccagagt tgtttctgaa acatggcaaa ggtagcgttg ccaatgatgt      780

tacagatgag atggtcagac taaactggct gacggaattt atgcctcttc cgaccatcaa      840

gcattttatc cgtactcctg atgatgcatg gttactcacc actgcgatcc ccgggaaaac      900

agcattccag gtattagaag aatatcctga ttcaggtgaa aatattgttg atgcgctggc      960

agtgttcctg cgccggttgc attcgattcc tgtttgtaat tgtcctttta acagcgatcg     1020

cgtatttcgt ctcgctcagg cgcaatcacg aatgaataac ggtttggttg atgcgagtga     1080

ttttgatgac gagcgtaatg gctggcctgt tgaacaagtc tggaaagaaa tgcataagct     1140

tttgccattc tcaccggatt cagtcgtcac tcatggtgat ttctcacttg ataaccttat     1200

ttttgacgag gggaaattaa taggttgtat tgatgttgga cgagtcggaa tcgcagaccg     1260

ataccaggat cttgccatcc tatggaactg cctcggtgag ttttctcctt cattacagaa     1320

acggcttttt caaaaatatg gtattgataa tcctgatatg aataaattgc agtttcattt     1380

gatgctcgat gagtttttct aactgtcaga ccaagtttac tcatatatac tttagattga     1440

tttaaaactt catttttaat ttaaaaggat ctaggtgaag atcctttttg ataatctcat     1500

gaccaaaatc ccttaacgtg agttttcgtt ccactgagcg tcagaccccg tagaaaagat     1560

caaaggatct tcttgagatc ctttttttct gcgcgtaatc tgctgcttgc aaacaaaaaa     1620

accaccgcta ccagcggtgg tttgtttgcc ggatcaagag ctaccaactc tttttccgaa     1680

ggtaactggc ttcagcagag cgcagatacc aaatactgtt cttctagtgt agccgtagtt     1740

aggccaccac ttcaagaact ctgtagcacc gcctacatac ctcgctctgc taatcctgtt     1800

accagtggct gctgccagtg gcgataagtc gtgtcttacc gggttggact caagacgata     1860

gttaccggat aaggcgcagc ggtcgggctg aacggggggt tcgtgcacac agcccagctt     1920

ggagcgaacg acctacaccg aactgagata cctacagcgt gagctatgag aaagcgccac     1980

gcttcccgaa gggagaaagg cggacaggta tccggtaagc ggcagggtcg gaacaggaga     2040

gcgcacgagg gagcttccag ggggaaacgc ctggtatctt tatagtcctg tcgggtttcg     2100

ccacctctga cttgagcgtc gatttttgtg atgctcgtca ggggggcgga gcctatggaa     2160

aaacgccagc aacgcggcct ttttacggtt cctggccttt tgctggcctt ttgctcacat     2220

gttctttcct gcgttatccc ctgattctgt ggataaccgt attaccgcct ttgagtgagc     2280

tgataccgct cgccgcagcc gaacgaccga gcgcagcgag tcagtgagcg aggaagcgga     2340

agagcgcctg atgcggtatt ttctccttac gcatctgtgc ggtatttcac accgcataga     2400

ccagccgcgt aacctggcaa aatcggttac ggttgagtaa taaatggatg ccctgcgtaa     2460

gcgggtgtgg gcggacaata aagtcttaaa ctgaacaaaa tagatctaaa ctatgacaat     2520

aaagtcttaa actagacaga atagttgtaa actgaaatca gtccagttat gctgtgaaaa     2580

agcatactgg acttttgtta tggctaaagc aaactcttca ttttctgaag tgcaaattgc     2640

ccgtcgtatt aaagaggggc gtggccaagg gcatggtaaa gactatattc gcggcgttgt     2700

gacaatttac cgaacaactc cgcggccggg aagccgatct cggcttgaac gaattgttag     2760

gtggcggtac ttgggtcgat atcaaagtgc atcacttctt cccgtatgcc caactttgta     2820

tagagagcca ctgcgggatc gtcaccgtaa tctgcttgca cgtagatcac ataagcacca     2880

agcgcgttgg cctcatgctt gaggagattg atgagcgcgg tggcaatgcc ctgcctccgg     2940

tgctcgccgg agactgcgag atcatagata tagatctcac tacgcggctg ctcaaacttg     3000

ggcagaacgt aagccgcgag agcgccaaca accgcttctt ggtcgaaggc agcaagcgcg     3060

atgaatgtct tactacggag caagttcccg aggtaatcgg agtccggctg atgttgggag     3120

taggtggcta cgtctccgaa ctcacgaccg aaaagatcaa gagcagcccg catggatttg     3180

acttggtcag ggccgagcct acatgtgcga atgatgccca tacttgagcc acctaacttt     3240

gttttagggc gactgccctg ctgcgtaaca tcgttgctgc tgcgtaacat cgttgctgct     3300

ccataacatc aaacatcgac ccacggcgta acgcgcttgc tgcttggatg cccgaggcat     3360

agactgtaca aaaaaacagt cataacaagc catgaaaacc gccactgcgc cgttaccacc     3420

gctgcgttcg gtcaaggttc tggaccagtt gcgtgagcgc atacgctact tgcattacag     3480

tttacgaacc gaacaggctt atgtcaactg ggttcgtgcc ttcatccgtt tccacggtgt     3540

gcgtcacccg gcaaccttgg gcagcagcga agtcgaggca tttctgtcct ggctggcgaa     3600

cgagcgcaag gtttcggtct ccacgcatcg tcaggcattg gcggccttgc tgttcttcta     3660

cggcaaggtg ctgtgcacgg atctgccctg gcttcaggag atcggaagac ctcggccgtc     3720

gcggcgcttg ccggtggtgc tgaccccgga tgaagtggtt cgcatcctcg gttttctgga     3780

aggcgagcat cgtttgttcg cccaggactc tagctatagt tctagtggtt ggctacagct     3840

tgcatgcctg caggcagctg cgcgctcgct cgctcactga ggccgcccgg gcgtcgggcg     3900

acctttggtc gcccggcctc agtgagcgag cgagcgcgca gagagggagt ggccaactcc     3960

atcactaggg gttccttgta gttaatgatt aacccgccat gctacttatc tacgtagcca     4020

tgctctagtg aattcgacgc cgccatctct aggcccgcgc cggccccctc gcacagactt     4080

gtgggagaag ctcggctact cccctgcccc ggttaatttg catataatat ttcctagtaa     4140

ctatagaggc ttaatgtgcg ataaaagaca gataatctgt tctttttaat actagctaca     4200

ttttacatga taggcttgga tttctataag agatacaaat actaaattat tattttaaaa     4260

aacagcacaa aaggaaactc accctaactg taaagtaatt gtgtgttttg agactataaa     4320

tatcccttgg agaaaagcct tgtttgcgtt tagtgaaccg tcagatggta ccgtttaaac     4380

tcgagtgagc gcagcaacga cctgaagatc gatccgtaaa gccacagatg gggtcgatct     4440

tcaggtcgtt gcttcgccta ctagagcggc cgccacagcg gggagatcca gacatgataa     4500

gatacatttt ttgaattcag gctatcccag gttgccttgg ttcttggcaa ttgggaaatt     4560

aagagggcag agagaatttg aacagaaact gttctaatat tggtctttta ttgtgtaagt     4620

attgttcttt ggtaaacctc cttcttttgg tttccaggaa ttgctggaca cagtggcttg     4680

gtgtgtgtct gaggactgta ggccttggcc ctaggttgtg gttttaggtc tcaggtgctc     4740

ttcctggctg tctccttgct tctttccctt gtcctcttct ttgtttccag ccttttctcc     4800

cttttgctta agtttggtgc agcagggttt ggctgctctc agattcctgc ttcctcagtt     4860

gctgtagttg tcaggcccag aaggctggca gaaggatcag gatctggcta ggtttgctct     4920

cactgtggca gagtaggggg aggaggagag caaaagtgac cccaggccag ctgtagggag     4980

cttaggcttg gtcaaccagc cttcaggtcc tagactttgt cttctcttga gtttggctgt     5040

gtgtgtttgg tgggaactag gttctactta gcccaagaaa ttgggcactt tttgcttgtg     5100

gtttctgtag agaattgcac tgggtatctg acttagcctg gcagcttgcc tccctcaggt     5160

aggttagtct caggaagtga agcaaagtcc agcaagaact tcttttgtgg cttaaagtct     5220

caattctgtg aggtgctggc aaatcaccac cacaatcaag aggctgaagt gatttttgtc     5280

tagggaggca ggaaaggctt cctggagtca gcagccagta ggtgaaagag tagattggag     5340

accttcttaa tcttcacaac ctcttgtctc aaggggtgcc aggaagctgt ggaggctgaa     5400

cccttctttt gctgccagag agtgggacac cttgagggtc aggtcaaggg gttgtacctt     5460

gtttggtaga gaattagggg ctcttgaaga ctttggttgt ggtcagggga gtgtatcttt     5520

taggaagagt gaccaagtga ggaagggtag aggaggacag gtgggaggga gtccaggtgg     5580

gagtgagtag acccagcagg agtgcagggc ctaaagccag gttggtggca gggctgtgag     5640

gagaggcagc cacctgtgtg tctgaagaag caggggcaag agggaagagg ccagcagact     5700

gccttcaccc agaaactgga atagattgtg agagaccttt ccctgctctt aggaggggct     5760

gagttccagt cctctcttgt tatacaaggg gcttggtatt tgtttacaaa aggggtgtaa     5820

agctagggca aggtttgata aggcttctag gggtatttaa gaagtattgt tggggtaatt     5880

gtttgtccaa ttaactttgc tcttggaagg actttcagta caaactgcaa caacaggatt     5940

aggaagggaa aatttctgag ttggggttac tcctcagaat ttcccagatt gtgatctggt     6000

tttgattttc aagcttgctg acccaatagg ttaacccaca agttttaacc agaccttctc     6060

agtccactta cttcaactgc ccttgccaaa gtccaagaga tcttaaactg ttgtttggca     6120

cagcttcctc cctcttgggt gggcaagctt ttggaagaga aggctccttt gggtgagagt     6180

ggggcaccaa agtcttccct gtcccttccc ctagcttgag aagcccttct ctattgtgga     6240

ctttgtgcaa ttagcttaat tactagcttg aagttgacct tctggaaata ctttctggtt     6300

tagcctcaca agtgagcaag gagggttgag agttgtgctg tgaggattgt ggggccccag     6360

ctggcagcag gctctgggtc aggggggcag ggaccaaagg cttacctgac agtgaggagg     6420

ggtctagtag gggatcagtt cccctgttgt tctttagaac cttctggata ttcttcttcc     6480

ctgattgggg gttgtgaaca atagaatcaa cttctacttg tagattgatt tagggagaac     6540

ttatacctca gttgttaagt caccctgtcc agattgtggg ttgctttcct atttgttcag     6600

aactttccca attacctcag aagcacttga aatttaaagg attttaaccc caacttaggg     6660

attatttcac ttagctcttg cacttttctt gataattgaa tcctcaggta ttcctctgtt     6720

tgggttacta atagttactt cttttggggg ggttttcccc tgaaaatctt ttatccccaa     6780

tttgtggctt accctctgaa ggttgtttga taattttgga agatttgaaa gtcttcttat     6840

tttacaaggt ttggggtctc tttaagctgc ttggttctct tgtcagctcc caaagcagaa     6900

gaaagctagc tgaaaattgc aatagagaag atacttcttt tccacctgtt ttcaactctt     6960

atcttcttga atttcagggc acctttcctt gctcctagtg cttgctatct gtttattatt     7020

ttccttcctg aataccctga actccagctt gttctgctgt aattctggcc tccctggctt     7080

cttggactcc tgtttccttt gctctgtctt cccccaagtc agctcctgct gaacagcttc     7140

tcagctgaag tgaacctgga gtgcctggat cttgctggat ctttgagtat tgcctctggg     7200

gtccttggtt ccttctgctg agttgctcag aatctccact cccccaacct tgtgtggccc     7260

ttcctgcact cctctgattc cccttgtctt ccctggtttc ttgctttggt ttaaagtctc     7320

cacagaactt ttgcagctct tctgaagacc tggaagcttt ttcttcttaa ttctcttctc     7380

ttgacctctt ttcccttctt tgagagctag aacttccctt ggtgaacttc tctttccaga     7440

attacttgcc ttcttttccc tcccacttac ctgttgtcca ggagaggtca gattgctgtg     7500

cttattggag gagaaccctt tcttccctgg gctcttcttc tcacttgact tcaccacttc     7560

acctaattcc ttggaccctc agtggtgtca ctgctggatt tttctttcct ttggctggcc     7620

ttagggcaca cccaggttga ctagaatagt cttggtattt agatccactc actttttcag     7680

tttctgtgtc tgtctcttgc ctgcttctga cttaacccag agaaagcttc tctttcacaa     7740

gggttcttag atttttgttc actgagcacc ttcttttctg aggcagtgtt ttaccaatag     7800

gggttttcct agtcagtcta accttacctt tcttgttggg cttgtctttg gtcctgaccc     7860

tttctctgag tctgtaaccc agaattgctg tataacccaa ttacttgaaa tcctttagaa     7920

tcttaacact tcttacacct gatttcccct tttattgtat ccaaattgaa ccaacccttt     7980

gtgaatttga cagtgatttc tcccagggat cctagtgtat aaggaatagg acttagtatt     8040

ttctattggg ggatatacca cttaccagat actgattttg ttggactttt aacccttttt     8100

tctctttttg aaagaaagtt aggaattatt tcttccagta gaaccagtgt aacctgaaag     8160

cctttgaaag agtagtttgg gtatagctat ctgaaaggaa tttctttcca agggatttcc     8220

ccagtgctga caacaaacaa acagacacac cctgcaaggt gagtgtaaag aacactagag     8280

caaggctacg tagataagta gcatggcggg ttaatcatta actacaagga acccctagtg     8340

atggagttgg ccactccctc tctgcgcgct cgctcgctca ctgaggccgg gcgaccaaag     8400

gtcgcccgac gcccgggctt tgcccgggcg gcctcagtga gcgagcgagc gcgcagctgc     8460

ctgcaggtct gagacaataa ccctgataaa tgcttcaata atgtaagctt gtcgagaagt     8520

actagaggat cataatcagc cataccacat ttgtagaggt tttacttgct ttaaaaaacc     8580

tcccacacct ccccctgaac ctgaaacata aaatgaatgc aattgaggcc ttaattctag     8640

ccataaaagg tcttgagcag gccgttgaaa acctcagccg tatcagcaaa acggcggtgc     8700

ctggtgccgc cgcaatgacc attaaccgcg ttgcttcatc cgcgatagcg cagtcggcgt     8760

cacaggttgc ccgtgagaca aaggtacgcc ggaaactggt aaaggaaagg gccaggctga     8820

aaagggccac ggtcaaaaat ccgcaggcca gaatcaaagt tagccggggg gatttgcccg     8880

taatcaagct gggtaatgcg cgggttgtcc tttcgcgccg caggcgtcgt aaaaaggggc     8940

agcgttcatc cctgaaaggt ggcggcagcg tgcttgtggt gggtaaccgt cgtattcccg     9000

gcgcgtttat tcagcaactg aaaaatggcc ggtggcatgt catgcagcgt gtggctggga     9060

aaaaccgtta ccccattgat gtggtgaaaa tcccgatggc ggtgccgctg accacggcgt     9120

tgaaacaaaa tagtgagcgg atacggcgtg aacgtcttcc gaaagagctg ggctatgcgc     9180

tgaagcatca actcacactg gtaataaagc gtagaaacat actgaacctc cgtgcagccg     9240

tactggatgc actggagaag catgacaccg gggcgacgtt ttttgatggt cgccccgctg     9300

tttttgatga ggcggatttt ccggcagttg ccgtttatct caccggcgct gaatacacgg     9360

gcgaagagct ggacagcgat acctggcagg cggagctgca tatcgaagtt ttcctgcctg     9420

ctcaggtgcc ggattcagag ctggatgcgt ggatggagtc ccggatttat ccggtgatga     9480

gcgatagccc ggcactgtca gatttgatca ccagtatggt gaccagcggc tatgactacc     9540

ggcgcgacga tgatgcgggc ttgtggagtt cagccgatct gacttatgtc attacctatg     9600

aaatgtctcc acgcttatga gcagcagact caacaggaca aaaatccgca gcagcagagc     9660

gataccgaag cgtcacggct gaaatatacc gaagaggcgc agaaggctta cgaacggctg     9720

aagacgccgc tggagaaata taccgcccgt caggaagaac tgaacaaggc actgaaagac     9780

gggaaaatcc tgaaggcgga ttacaacacg ctgatggcgg cggcgaaaaa ggattatgaa     9840

gcgacgctga aaaagccgaa acagtccagc gtgaaggtgt ctgcgggcga tagtcaggaa     9900

gacagtgctc atgctgccct gctgacgctt caggcagaac tcctgacgct ggagaagcaa     9960

gccggagcaa atgagaaaat cagccagcag cgccgggatt tgtggaaggc ggagagtcag    10020

ttcgcggtac tggaggaggc ggcgcaacgt cgccaggtgt ctgcacagga gaaatccctg    10080

ctggcgcata aagatgagac gctggagtac aaacgccagg tggctgcact tggcgacaag    10140

gttaggtatc aggagcgcct gaacgcgctg gcgcagcagg cggataaatt cgcacagcag    10200

caacgggcaa aacgggccgc cattgatgcg aaaagccggg ggctgactga ccggcaggca    10260

gaacgggaag ccacggaaca gcgcctgaag gaacagtatg gcgataatcc gctggcgctg    10320

aataacgtca tgtcagagca gaaaaagacc tgggcggctg aagaccagct tcgcgggaac    10380

tggatggcag acctgaagtc cggctggagt gagtgggaag agagcgccac ggacagtatg    10440

tcgcaggtaa aaagtgcagc cacgcagacc tttgatggta ttgcacagaa tatggcggcg    10500

atgctgaccg gcagtgagca gaactggcgc agcttcaccc gttccgtgct gtccatgatg    10560

acagaaattc tgctttagca ggcaatggtg gggattgtcg ggagtatcgg cagcgccatt    10620

ggcggggctg ttggtggcgg cgcatccgcg tcaggcggta cagccattca ggccgctgcg    10680

gcgaaattcc attttgcaac cggaggattt acgggaaccg gcggcaaata tgagccagcg    10740

gggattgttc accgtggtga gtttgtcttc acgaaggagg caaccagccg gattggcgtg    10800

gggaatcttt accggctgat gcgcggctat gccaccggcg gttatgtcgg tacaccgggc    10860

agcatggcag acagccggtc gcaggcgtcc gggacgtttg agcagaataa ccatgtggtg    10920

attaacaacg acggcacgaa cgggcagata ggtccggctg ctctgaaggc ggtgtatgac    10980

atggcccgca agggtgcccg tgatgaaatt cagacacaga tgcgtgatgg tggcctgttc    11040

tcctgacctc cacgatgagg cgcgcccaat tgttgttgtt aacttgttta ttgcagctta    11100

taatggttac aaataaagca atagcatcac aaatttcaca aataaagcat ttttttcact    11160

gcattctagt tgtggtttgt ccaaactcat caatgtatct tatcatgtct ggatctgatc    11220

actgatatcg cctaggagat ccgaaccaga taagtgaaat ctagttccaa actattttgt    11280

catttttaat tttcgtatta gcttacgacg ctacacccag ttcccatcta ttttgtcact    11340

cttccctaaa taatccttaa aaactccatt tccacccctc ccagttccca actattttgt    11400

ccgcccacag cggggcattt ttcttcctgt tatgttttta atcaaacatc ctgccaactc    11460

catgtgacaa accgtcatct tcggctactt tttctctgtc acagaatgaa aatttttctg    11520

tcatctcttc gttattaatg tttgtaattg actgaatatc aacgcttatt tgcagcctga    11580

atggcgaatg g                                                         11591


